Recent Research
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BILIARY ATRESIA IN CANADA
Neurodevleopmental Outcomes in Pre-School and School Aged Children with Biliary Atresia and their Native Liver
Squires JE, Ng VL, Hawthorne K, Henn L, Sorensen LG, Fredericks EM, Alonso EM, Murray KF, Loomes KM, Karpen SJ, Cavallo LA, Molleston JP, Bezerra JA, Rosenthal P, Squires RH, Wang KS, Schwarz KB, Arnon R, Magee JC, Sokol RJ, Childhood Liver Disease Research Network (ChiLDReN). J Pediatr Gastroenterol. 2019 Sept; doi: 10.1097/MPG.0000000000002489Universal screening for newborns for biliary atresia: Cost-effectiveness of alternative strategies.
Masucci, L; Schreiber, RA; Kaczorowski, J; Collet, J; Bryan, S. J Med Screen. 2019 Sept; 26(3), 113-119.The Role of Liver Biopsy in Investigation of Cholestatic Liver Disease in Infancy.
Chaudhry, Z; Forget, S; Nguyen VH; Ahmed, N. J Can Assoc Gastroenterol. 2019 May; 2(2), 51-56.Province-wide Biliary Atresia Home Screening Program in British Columbia: Evaluation of the First 2 Years.
Woolfson, JP; Schreiber, R; Butler, AE; MacFarlane, J; Kaczorowski, J; Masucci, L; Bryan, S; Collet, JP. J Pediatr Gastroenterol Nutr. 2018 June; 66(6), 845-849.Screening for Biliary Atresia: it’s in the cards
Schreiber, Richard A. & Butler, Alison. Can Fam Physician 2017 June; 63(6);426-427.Variability of diagnostic approach, surgical technique, and medical management for children with biliary atresia in Canada- Is it time for standardization?
Stagg, H; Cameron, Brian H; Ahmed, Najma; Butler, A; Jimenez-Rivera, Carolina; Yanchar, Natalie L; Martin, Steve R; Emil, Sherif; Anthopoulos, George; Schreiber, Richard A; Laberge, Jean-Martin; the Canadian Biliary Atresia Registry. J Pediatr Surg. 2017 May; 52(5): 802-806. doi: 10.1016/j.jpedsurg.2017.01.041Biliary Atresia in Canada: The Effect of Centre Caseload Experience on Outcome
Schreiber, Richard A; Barker, Collin C; Roberts, Eve A; Martin, Steven R; and the Canadian Pediatric Hepatology Research Group J Pediatr Gastroenterol Nutr. 2010 July; 51(1): 61–65. doi: 10.1097/MPG.0b013e3181d67e5eBiliary Atresia: The Timing Needs a Changin’
Ehsan Chitsaz, Richard A. Schreiber, Jean-Paul Collet, Janusz Kaczorowski Can J Public Health 2009;100(6):475-77.Biliary atresia: the Canadian experience.
Schreiber RA, Barker CC, Roberts EA, Martin SR, Alvarez F, Smith L, Butzner JD, Wrobel I, Mack D, Moroz S, Rashid M, Persad R, Levesque D, Brill H, Bruce G, Critch J; Canadian Pediatric Hepatology Research Group. J Pediatr. 2007 Dec;151(6):659-65, 665.e1. Epub 2007 Oct 22. -
BILIARY ATRESIA INTERNATIONAL OUTCOMES
Biliary atresia as a disease starting in utero: Implications for Treatment, Diagnosis and Pathogenesis
Maysore KR, Shneider BL, Harpavat S, JPGN. 2019;69: 396-403.Prognosis of Biliary Atresia after 2-year survival with native liver: a nationwide cohort analysis
Witt, M; van Wessel, DBE; de Kleine, RHJ; Bruggink, JLM; Hulscher, JBF; Verkade, HJ; Nesbar. J Pediatr Gastroenterol Nutr, 2018 Dec, 67(6),689-694.Learning curve of laparoscopic Kasai portoenterostomy for biliary atresia: a report of 100 cases
Y, Ji; Yang, K; Zhang, X; Chen, S, Z, Xu. BMC Surg. 2018 Nov 26. doi:10.1186/s12893-018-0443yJapanese Biliary Atresia Registry
Nio, M. Pediatr Surg Inter, 2017 Dec, 32(12), 1319-1325.Incidence of Biliary Atresia and timing of hepatoportoenterostomy in the United States
Hopkins, PC; Yazigi, N; Nylund CM. J Pediatr, 2017 Aug, 187, 253-257.Biliary atresia in preterm infants in Taiwan: a nationwide survey.
Chiu CY, Chen PH, Chan CF, Chang MH, Wu TC; Taiwan Infant Stool Color Card Study Group. J Pediatr. 2013 Jul;163(1):100-3.e1. doi: 10.1016/j.jpeds.2012.12.085. Epub 2013 Feb 12.Improving outcomes of biliary atresia: French national series 1986-2009.
Chardot C, Buet C, Serinet MO, Golmard JL, Lachaux A, Roquelaure B, Gottrand F, Broué P, Dabadie A, Gauthier F, Jacquemin E. J Hepatol. 2013 Jun;58(6):1209-17. doi: 10.1016/j.jhep.2013.01.040. Epub 2013 Feb 8.Scottish outcomes for extra hepatic biliary atresia post-rationalisation of services.
Tayler R, Barclay AR, Rogers P, Mcintyre K, Russell RK, Devadason D, Bisset WM, Ling SC, McGrogan P. Arch Dis Child. 2013 May;98(5):381-3. doi: 10.1136/archdischild-2011-301608. Epub 2013 Feb 21. -
REFERRAL
Stool color card screening for early detection of biliary atresia and long-term native liver survival: a 19-year cohort study in Japan.
Gu YH, Yokoyama K, Mizuta K, Tsuchioka T, Kudo T, Sasaki H, et al. J Pediatr. 2015 Apr;166(4):897-902.e1. doi: 10.1016/j.jpeds.2014.12.063. Epub 2015 Feb 11.Home-based screening for biliary atresia using infant stool colour cards: a large-scale prospective cohort study and cost-effectiveness analysis.
Schreiber RA, Masucci L, Kaczorowski J, Collet JP, Lutley P, Espinosa V, Bryan S. J Med Screen. 2014 Sep;21(3):126-32. doi: 10.1177/0969141314542115. Epub 2014 Jul 9. -
DIAGNOSIS
Needle Liver Biopsy Has Potential for Delaying Kasai Portoenterostomy and Is Obsolete for Diagnosing Biliary Atresia in the Laparoscopic Era.
Okazaki C, Ochi T, Nakamura H, Tsuki T, Koga, H, Urao, M, Lane GJ, Yamataka, A.J Pediatr Surg. 2019 Aug; doi: 10.1016/j.jpedsurg.2019.08.028A quantitative image analysis using MRI for diagnosis of biliary atresia.
Lin DC, Wu KY, Sun FJ, Huang CC, Shih SL, Tsai PS. Clin Imaging. 2019 Feb; 53:186-190.Diagnostic Accuracy of Serum Matrix Metalloproteinase-7 for Biliary Atresia.
Yang L, Zhou Y, Xu PP, et al. Hepatology. 2018; 68(6):2069-2077.Biliary tract: MMP-7 — a diagnostic marker for biliary atresia.
Thomas H. Nature Reviews Gastroenterology & Hepatology. 2018; 15(2): 68.A screening algorithm for the efficient exclusion of biliary atresia in infants with cholestatic jaundice.
Jancelewicz T, Barmherzig R, Chung CT, Ling SC, Kamath BM, Ng VL, Amaral J, O’Connor C, Fecteau A, Langer JC.J Pediatr Surg. 2015 Mar;50(3):363-70. doi: 10.1016/j.jpedsurg.2014.08.014.Differentiating biliary atresia from other causes of cholestatic jaundice.
Robie DK, Overfelt SR, Xie L. Am Surg. 2014 Sep;80(9):827-31.Transient elastography and sonography for prediction of liver fibrosis in infants with biliary atresia.
Shin NY, Kim MJ, Lee MJ, Han SJ, Koh H, Namgung R, Park YN. J Ultrasound Med. 2014 May;33(5):853-64. doi: 10.7863/ultra.33.5.853.Design and validation of a diagnostic score for biliary atresia.
El-Guindi MA, Sira MM, Sira AM, Salem TA, El-Abd OL, Konsowa HA, El-Azab DS, Allam AA. J Hepatol. 2014 Jul;61(1):116-23.Three-dimensional magnetic resonance cholangiopancreatography for the diagnosis of biliary atresia in infants and neonates.
Liu B, Cai J, Xu Y, Peng X, Zheng H, Huang K, Yang J. PLoS One. 2014 Feb 5;9(2):e88268. doi: 10.1371/journal.pone.0088268. eCollection 2014.Identification of the plasma metabolomics as early diagnostic markers between biliary atresia and neonatal hepatitis syndrome.
Zhao D, Han L, He Z, Zhang J, Zhang Y. PLoS One. 2014 Jan 8;9(1):e85694. doi: 10.1371/journal.pone.0085694. eCollection 2014.Morphometric assessment of liver fibrosis may enhance early diagnosis of biliary atresia. Abdalla AF, Fathy A, Zalata KR, Megahed A, Abo-Alyazeed A, El Regal ME. World J Pediatr. 2013 Nov;9(4):330-5. doi: 10.1007/s12519-013-0423-3. Epub 2013 Jun 17.
The diagnostic value of high-frequency ultrasonography in biliary atresia. Jiang LP, Chen YC, Ding L, Liu XL, Li KY, Huang DZ, Zhou AY, Zhang QP. Hepatobiliary Pancreat Dis Int. 2013 Aug;12(4):415-22.
Analysis of clinical parameters that contribute to the misdiagnosis of biliary atresia. Sun S, Chen G, Zheng S, Xiao X, Xu M, Yu H, Dong R. J Pediatr Surg. 2013 Jul;48(7):1490-4. doi: 10.1016/j.jpedsurg.2013.02.034.
Ultrasound scanning in infants with biliary atresia: the different implications of biliary tract features and liver echostructure.
Iorio R, Liccardo D, Di Dato F, Puoti MG, Spagnuolo MI, Alberti D, Vallone G. Ultraschall Med. 2013 Oct;34(5):463-7. doi: 10.1055/s-0033-1335455. Epub 2013 May 21.Value of hepatic subcapsular flow by color Doppler ultrasonography in the diagnosis of biliary atresia.
El-Guindi MA1, Sira MM, Konsowa HA, El-Abd OL, Salem TA. J Gastroenterol Hepatol. 2013 May;28(5):867-72. doi: 10.1111/jgh.12151.Accuracy of hepatobiliary scintigraphy for differentiation of neonatal hepatitis from biliary atresia: systematic review and meta-analysis of the literature. Kianifar HR, Tehranian S, Shojaei P, Adinehpoor Z, Sadeghi R, Kakhki VR, Keshtgar AS. Pediatr Radiol. 2013 Aug;43(8):905-19. doi: 10.1007/s00247-013-2623-3. Epub 2013 Mar 22.
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OUTCOME PREDICTORS
Serum autotaxin levels correlate with hepatic dysfunction and severity in postoperative biliary atresia.
Udomsinprasert W, Honsawek S, Anomasiri W, Chongsrisawat V, Vejchapipat P, Poovorawan Y. Biomarkers. 2015 Feb;20(1):89-94. doi: 10.3109/1354750X.2014.994564. Epub 2014 Dec 24.The degree of spleen stiffness measured on acoustic radiation force impulse elastography predicts the severity of portal hypertension in patients with biliary atresia after portoenterostomy.Uchida H, Sakamoto S, Kobayashi M, Shigeta T, Matsunami M, Sasaki K, Kanazawa H, Fukuda A, Kanamori Y, Miyasaka M, Nosaka S, Kawagishi N, Kasahara M. J Pediatr Surg. 2015 Apr;50(4):559-64. doi: 10.1016/j.jpedsurg.2014.12.026. Epub 2015 Jan 14.
Long-term native liver fibrosis in biliary atresia: development of a novel scoring system using histology and standard liver tests.
Tomita H, Masugi Y, Hoshino K, Fuchimoto Y, Fujino A, Shimojima N, Ebinuma H, Saito H, Sakamoto M, Kuroda T. J Hepatol. 2014 Jun;60(6):1242-8. doi: 10.1016/j.jhep.2014.01.028. Epub 2014 Feb 15.The most reliable early predictors of outcome in patients with biliary atresia after Kasai’s operation.
Goda T, Kawahara H, Kubota A, Hirano K, Umeda S, Tani G, et al. J Pediatr Surg. 2013 Dec;48(12):2373-7. doi: 10.1016/j.jpedsurg.2013.08.009.Clinical benefit of liver stiffness measurement at 3 months after Kasai hepatoportoenterostomy to predict the liver related events in biliary atresia.
Hahn SM1, Kim S, Park KI, Han SJ, Koh H. PLoS One. 2013 Nov 18;8(11):e80652. doi: 10.1371/journal.pone.0080652. eCollection 2013.Factors influencing jaundice-free survival with the native liver in post-portoenterostomy biliary atresia patients: results from a single institution.
Koga H1, Wada M, Nakamura H, Miyano G, Okawada M, Lane GJ, Okazaki T, Yamataka A. J Pediatr Surg. 2013 Dec;48(12):2368-72. doi: 10.1016/j.jpedsurg.2013.08.007Aspartate Aminotransferase-to-Platelet ratio index (APRi) in infants with biliary atresia: prognostic value at presentation.
Grieve A, Makin E, Davenport M. J Pediatr Surg. 2013 Apr;48(4):789-95. doi: 10.1016/j.jpedsurg.2012.10.010. -
SURGERY
Predictors of Successful Kasai Portoenterostomy and Survival with Native Liver at 2 Years in Infants with Biliary Atresia.
Kumar R, Lal BB, Sood V, Khanna R, Kumar S, et al. J Clinc Exp Hepatol, 2019 Aug;9(4), 453-459.Factors associated with timing and adverse outcomes in patients with Biliary Atresia undergoing Kasai Hepatoportoenterostomy
Townsend, MR; Jaber, A; Abi Nader, H; Eid, SM; Schwarz, K. J Pediatr, 2018 Aug, 199, 237-242.Learning curve of laparoscopic Kasai portoenterostomy for biliary atresia: a report of 100 cases
Y, Ji; Yang, K; Zhang, X; Chen, S, Z, Xu. BMC Surg. 2018 Nov 26. doi:10.1186/s12893-018-0443yEarly Posthepatoportoenterostomy Predictors of Native Liver Survival in Biliary Atresia.
Nightingale, S; Stormon, MO; O’Loughlin, EV; Shun, A; Thomas, G; Benchimol, EI; Day, AS; Adams, S; Shi, E; Ooi, CY; Kamath, BM; Fecteau, A; Langer, JC; Roberts, EA; Ling, SC; Ng, VL. J. Pediatr Gastroenterol Nutr, 2017, 64, 203-209.Does pneumoperitoneum adversely affect growth, development and liver function in biliary atresia patients after laparoscopic portoenterostomy?
Nakamura H, Koga H, Okazaki T, Urao M, Miyano G, Okawada M, et al. Pediatr Surg Int. 2015 Jan;31(1):45-51. doi: 10.1007/s00383-014-3625-4. Epub 2014 Oct 18.The experience and technique in laparoscopic portoenterostomy for biliary atresia.
Wang B, Feng Q, Ye X, Zeng S. J Laparoendosc Adv Surg Tech A. 2014 May;24(5):350-3. doi: 10.1089/lap.2013.0138. Epub 2014 Jan 21.Laparoscopic Kasai portoenterostomy for biliary atresia.
Yamataka A. J Hepatobiliary Pancreat Sci. 2013 Jun;20(5):481-6. doi: 10.1007/s00534-013-0607-1.From laparoscopic to open Kasai portoenterostomy: the outcome after reintroduction of open Kasai portoenterostomy in infant with biliary atresia.
Chan KW, Lee KH, Wong HY, Tsui SY, Wong YS, Pang KY, Mou JW, Tam YH. Pediatr Surg Int. 2014 Jun;30(6):605-8. doi: 10.1007/s00383-014-3499-5. Epub 2014 Apr 11.Redo surgery for biliary atresia.
Nio M1, Sasaki H, Tanaka H, Okamura A. Pediatr Surg Int. 2013 Oct;29(10):989-93. doi: 10.1007/s00383-013-3396-3 -
POST-SURGICAL TREATMENT
Total serum bilirubin predicts fat-soluble vitamin deficiency better than serum bile acids in infants with biliary atresia.
Venkat VL, Shneider BL, Magee JC, Turmelle Y, Arnon R, Bezerra JA, et al. J Pediatr Gastroenterol Nutr. 2014 Dec;59(6):702-7. doi: 10.1097/MPG.0000000000000547.Use of corticosteroids after hepatoportoenterostomy for bile drainage in infants with biliary atresia: the START randomized clinical trial.
Bezerra JA, Spino C, Magee JC, Shneider BL, Rosenthal P, Wang KS, et al. JAMA. 2014 May 7;311(17):1750-9. doi: 10.1001/jama.2014.2623Postoperative morphine concentration in infants with or without biliary atresia and its association with hepatic blood flow.
Wang X1, Qiao ZW, Zhou ZJ, Zhuang PJ, Zheng S. Anaesthesia. 2014 Jun;69(6):583-90. doi: 10.1111/anae.12624. Epub 2014 Apr 18.Multicenter randomized trial of postoperative corticosteroid therapy for biliary atresia.
Japanese Biliary Atresia Society, Nio M, Muraji T. Hepatology. Pediatr Surg Int. 2013 Nov;29(11):1091-5. doi: 10.1007/s00383-013-3377-6.Steroids in biliary atresia: single surgeon, single centre, prospective study. Davenport M, Parsons C, Tizzard S, Hadzic N. J Hepatol. 2013 Nov;59(5):1054-8. doi: 10.1016/j.jhep.2013.06.012. Epub 2013 Jun 25.
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COMPLICATIONS
Cholangitis in children with biliary atresia: health-care resource utilisation. J Paediatr Child Health.
Lee JY, Lim LT, Quak SH, Prabhakaran K, Aw M. 2014 Mar;50(3):196-201. doi: 10.1111/jpc.12463. Epub 2013 Dec 23.Hepatic tumours in children with biliary atresia: single-centre experience in 13 cases and review of the literature.
Yoon HJ, Jeon TY, Yoo SY, Kim JH, Eo H, Lee SK, Kim JS. Clin Radiol. 2014 Mar;69(3):e113-9. doi: 10.1016/j.crad.2013.10.017. Epub 2013 Dec 9.Experience with endoscopic management of high-risk gastroesophageal varices, with and without bleeding, in children with biliary atresia. Duché M, Ducot B, Ackermann O, Baujard C, Chevret L, Frank-Soltysiak M, Jacquemin E, Bernard O. Gastroenterology. 2013 Oct;145(4):801-7. doi: 10.1053/j.gastro.2013.06.022. Epub 2013 Jun 19.
Assessment of risk of bleeding from esophageal varices during management of biliary atresia in children.
Wanty C, Helleputte T, Smets F, Sokal EM, Stephenne X. J Pediatr Gastroenterol Nutr. 2013 May;56(5):537-43. doi: 10.1097/MPG.0b013e318282a22c. -
LONG TERM OUTCOMES
Biliary atresia: 20-40 year followup with native liver in an Italian centre.
Parolini F, Boroni G, Milanti S, Tonegatti L, et al. J Pediatr Surg; 2019 July, 54(7): 1440-1444Impact of steroid therapy on early growth in infants with Biliary Atresia: the multicenter steroids in Biliary Atresia randomized trial
Alonso, EM; Ye, W; Hawthorne, K; Venkat, V; Loomes, KM; Mack, CL; Hertel, PM; Karpen, SJ; Kerkar, N; Molleston, JP; Murray, KF; Romero, R; Rosenthal, P; Schwarz, KB; Shneider, BL; Suchy, FJ; Turmelle, YP; Wang, KS; Sherker, AH; Sokol, RJ; Bezerra, JA; Magee, JC. J Pediatr. 2018 Nov. doi:10.1016/j.jpeds.2018.07.002Health status and quality of life in adult biliary atresia patients surviving with their native livers.
Lind RC, de Vries W, Keyzer-Dekker CM, Peeters PM, Verkade HJ, Hoekstra-Weebers JE, van der Steeg AF, Hulscher JB. Eur J Pediatr Surg. 2015 Feb;25(1):60-5. doi: 10.1055/s-0034-1387941. Epub 2014 Aug 30.Medical status of 219 children with biliary atresia surviving long-term with their native livers: results from a North American multicenter consortium.
Ng VL, Haber BH, Magee JC, Miethke A, Murray KF, Michail S, Karpen SJ, Kerkar N, Molleston JP, Romero R, Rosenthal P, Schwarz KB, Shneider BL, Turmelle YP, Alonso EM, Sherker AH, Sokol RJ; Childhood Liver Disease Research and Education Network (CHiLDREN).J Pediatr. 2014 Sep;165(3):539-546.e2. doi: 10.1016/j.jpeds.2014.05.038. Epub 2014 Jul 9.Health related quality of life in patients with biliary atresia surviving with their native liver.
Sundaram SS, Alonso EM, Haber B, Magee JC, Fredericks E, Kamath B, Kerkar N, Rosenthal P, Shepherd R, Limbers C, Varni JW, Robuck P, Sokol RJ; Childhood Liver Disease Research and Education Network (ChiLDREN). J Pediatr. 2013 Oct;163(4):1052-7.e2. doi: 10.1016/j.jpeds.2013.04.037. Epub 2013 Jun 6.Long-term results of biliary atresia in the era of liver transplantation.
Lee S1, Park H, Moon SB, Jung SM, Kim JM, Kwon CH, Kim SJ, Joh JW, Seo JM, Lee SK. Pediatr Surg Int. 2013 Dec;29(12):1297-301. doi: 10.1007/s00383-013-3366-9. Epub 2013 Aug 15.The long-term outcome of the Kasai operation in patients with biliary atresia: a systematic review.
Bijl EJ1, Bharwani KD, Houwen RH, de Man RA. Neth J Med. 2013 May;71(4):170-3. -
PATHOLOGY
Complement C5/5a are druggable targets and attenuate duct atresia and liver inflammation in experimental biliary atresia.
Navabi N, Gutta S, Mourya et al. Hepatology, 2019 Oct;70S:15ABiliary Atresia: Clinical and research challenges for the twenty-first century
Bezerra, JA; Wells, RG; Mack, CL; Karpen, SJ; Hoofnagle, JH; Doo, E; Sokol, RJ. Hepatology, 2018 Sept, 68(3), 1163-1173miR-222 overexpression may contribute to liver fibrosis in biliary atresia by targeting PPP2R2A.
Dong R, Zheng Y, Chen G, Zhao R, Zhou Z, Zheng S. J Pediatr Gastroenterol Nutr. 2015 Jan;60(1):84-90. doi: 10.1097/MPG.0000000000000573.The expression of epithelial-mesenchymal transition-related proteins in biliary epithelial cells is associated with liver fibrosis in biliary atresia.
Xiao Y, Zhou Y, Chen Y, Zhou K, Wen J, Wang Y, Wang J, Cai W. Pediatr Res. 2015 Feb;77(2):310-5. doi: 10.1038/pr.2014.181. Epub 2014 Nov 19.MicroRNA-21/PTEN/Akt axis in the fibrogenesis of biliary atresia.
Shen W, Chen G, Dong R, Zhao R, Zheng S. J Pediatr Surg. 2014 Dec;49(12):1738-41. doi: 10.1016/j.jpedsurg.2014.09.009. Epub 2014 Nov 13.Integrin β-8, but not β-5 or -6, protein expression is increased in livers of children with biliary atresia.
Iordanskaia T, Koeck E, Rossi C, Mohan P, Schwarz K, Anders R, Nadler EP. J Pediatr Gastroenterol Nutr. 2014 Dec;59(6):679-83. doi: 10.1097/MPG.0000000000000518.Association between single nucleotide polymorphisms in the ADD3 gene and susceptibility to biliary atresia.
Zeng S, Sun P, Chen Z, Mao J, Wang J, Wang B, et al. PLoS One. 2014 Oct 6;9(10):e107977. doi: 10.1371/journal.pone.0107977. eCollection 2014.Positive C4d staining of the portal vein endothelium in the liver of patients with biliary atresia: a role of humoral immunity in ongoing liver fibrosis.
Fujisawa S, Muraji T, Sakamoto N, Hosaka N, Matsuda S, Kawakami H, Hirai M, Yanai T. Pediatr Surg Int. 2014 Sep;30(9):877-81.Up-regulation of miR-200b in biliary atresia patients accelerates proliferation and migration of hepatic stallate cells by activating PI3K/Akt signaling.
Xiao Y, Wang J, Chen Y, Zhou K, Wen J, Wang Y, Zhou Y, Pan W, Cai W. Cell Signal. 2014 May;26(5):925-32. doi: 10.1016/j.cellsig.2014.01.003. Epub 2014 Jan 8.HMGB1-promoted and TLR2/4-dependent NK cell maturation and activation take part in rotavirus-induced murine biliary atresia.
Qiu Y1, Yang J1, Wang W1, Zhao W1, Peng F1, Xiang Y2, Chen G2, Chen T3, Chai C1, Zheng S1, Watkins DJ4, Feng J1. PLoS Pathog. 2014 Mar 20;10(3):e1004011. doi: 10.1371/journal.ppat.1004011. eCollection 2014.Perforin and granzymes work in synergy to mediate cholangiocyte injury in experimental biliary atresia.
Shivakumar P, Mourya R, Bezerra JA. J Hepatol. 2014 Feb;60(2):370-6. doi: 10.1016/j.jhep.2013.09.021. Epub 2013 Oct 2.Maternal microchimerism in biliary atresia: are maternal cells effector cells, targets, or just bystanders?
Muraji T. Chimerism. 2014 Jan-Mar;5(1):1-5. doi: 10.4161/chim.28576. Epub 2014 Mar 26.Gene expression signature for biliary atresia and a role for interleukin-8 in pathogenesis of experimental disease.
Bessho K1, Mourya R, Shivakumar P, Walters S, Magee JC, Rao M, Jegga AG, Bezerra JA. Hepatology. 2014 Jul;60(1):211-23. doi: 10.1002/hep.27045. Epub 2014 May 27.Elevated Th17 cells accompanied by decreased regulatory T cells and cytokine environment in infants with biliary atresia.
Yang Y, Liu YJ, Tang ST, Yang L, Yang J, Cao GQ, Zhang JH, Wang XX, Mao YZ. Pediatr Surg Int. 2013 Dec;29(12):1249-60.Extrahepatic anomalies in infants with biliary atresia: results of a large prospective North American multicenter study. Schwarz KB, Haber BH, Rosenthal P, Mack CL, Moore J, Bove K, Bezerra JA, Karpen SJ, Kerkar N, Shneider BL, Turmelle YP, Whitington PF, Molleston JP, Murray KF, Ng VL, Romero R, Wang KS, Sokol RJ, Magee JC; Childhood Liver Disease Research and Education Network. Hepatology. 2013 Nov;58(5):1724-31. doi: 10.1002/hep.26512. Epub 2013 Sep 19.
Aetiology of biliary atresia: what is actually known?
Petersen C, Davenport M. Orphanet J Rare Dis. 2013 Aug 29;8:128. doi: 10.1186/1750-1172-8-128. -
TRANSPLANTATION
Predictors of Need for Liver Transplantation in Children Undergoing Hepatoportoenterostomy for Biliary Atresia.
Ramos-Gonzalez G, Elisofon S, Dee EC, et al. J Pediatr Surg, 2019 Jun;54(6), 1127-1131.Biliary-enteric draining vs primary liver transplant as initial treatment for children with Biliary Atresia.
LeeVan, E; Matsuoka, L; Cao, S; Groshen, S; Alexopoulos, S. JAMA Surg, 2018 Sep 12; doi:10.1001/jamasurg.2018.3180What is the optimal timing of liver transplantation for children with biliary atresia? A Markov model simulation analysis.
Arnon R1, Leshno M, Annunziato R, Florman S, Iyer K. J Pediatr Gastroenterol Nutr. 2014 Sep;59(3):398-402. doi: 10.1097/MPG.0000000000000428.Living-donor liver transplantation for congenital biliary atresia with porto-pulmonary hypertension and moderate or severe pulmonary arterial hypertension: Kyoto University experience.
Ogawa E, Hori T, Doi H, Segawa H, Uemoto S. Clin Transplant. 2014 Sep;28(9):1031-40. doi: 10.1111/ctr.12415. Epub 2014 Jul 28.Beyond the Pediatric end-stage liver disease system: solutions for infants with biliary atresia requiring liver transplant.
Tessier ME, Harpavat S, Shepherd RW, Hiremath GS, Brandt ML, Fisher A, Goss JA. World J Gastroenterol. 2014 Aug 28;20(32):11062-8.Outcomes in children with biliary atresia following liver transplantation. Sun LY, Yang YS, Zhu ZJ, Gao W, Wei L, Sun XY, Qu W, Rao W, Zeng ZG, Dong C, Tu JP, Wang J, Liu YH, Liu Y, Yu LX, Wang Y, Li J, Shen ZY. Hepatobiliary Pancreat Dis Int. 2013 Apr;12(2):143-8.
Effect of repeat Kasai hepatic portoenterostomy on pediatric live-donor liver graft for biliary atresia.
Urahashi T, Ihara Y, Sanada Y, Wakiya T, Yamada N, Okada N, Mizuta K. Exp Clin Transplant. 2013 Jun;11(3):259-63. doi: 10.6002/ect.2012.0188. Epub 2013 Mar 26.The pre-Kasai procedure in living donor liver transplantation for children with biliary atresia.
Wang Q, Yan LN, Zhang MM, Wang WT, Zhao JC, Pu CL, Li YC, Kang Q. Hepatobiliary Pancreat Dis Int. 2013 Feb;12(1):47-53.Serial ultrasound findings associated with early liver transplantation after Kasai portoenterostomy in biliary atresia.
Jeon TY, Yoo SY, Kim JH, Eo H, Lee SK. Clin Radiol. 2013 Jun;68(6):588-94. doi: 10.1016/j.crad.2012.12.004. Epub 2013 Jan 23.
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